Cities and their peripheries are constantly confronted with challenges such as urban sprawl, climate change and pollution. These processes can exacerbate the degradation of natural ecosystems, and jeopardize ecosystem service provisioning with negative consequences for human health and well-being, biodiversity, social cohesion and equity, and, finally, city resilience. The INTERLACE project brings together a unique consortium of European and Latin American partners to contribute to effectively restoring and rehabilitating urban ecosystems to make cities more livable, resilient and inclusive. The project aims to advance knowledge and awareness of restorative nature-based solutions (NBS), such as the restoration of wetlands and rivers, as well as to foster more ecologically coherent and integrated city planning processes. In addition, it lays the foundation for sustained multi-directional cooperation and exchange between European and Latin American cities for wider transformative impact.